BT000040: A2 (Disialo 2,3) Glycan-sp-Biotin (6-aminohexanoic acid spacer)

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Description

BT000040: A2 (Disialo 2,3) Glycan-sp-Biotin (6-aminohexanoic acid spacer)C104H169N11O67S 2677. 55 An A2 biantennary disialo (2 3) N glycan equipped with a biotin tag through a 6 aminohexanoic acid spacer. The biotin moiety binds with high affinity to streptavidin and neutravidin, enabling straightforward immobilization on chips, in wells, or on other streptavidin neutravidin coated platforms. This compound presents an A2 biantennary N glycan capped with 2 3 linked sialic acid (disialo) on an Asn core, mimicking native

75 / A core 1 / T antigen (Galβ1-3GalNAcα) on a threonine residue equipped with a biotin tag through an amide bond

The sugar hydroxyl groups are protected as acetate esters (peracetate)

C16H14O12SNa2 / 476

58 / An α-D-N-acetylgalactosamine (GalNAcα) ligand on a serine residue (Tn antigen

93 / An Fmoc-protected L-threonine building block carrying a GlcNAcβ1-3GalNAcα disaccharide

β-D-GalNAc-Bu-COOH

/ α-D-Man-Ethyl-Azide / α-Man-Et-N3

Used as a fluorogenic substrate for glycosidases acting on the GAG linkage region or related xylose/glucuronic acid linkages

followed by cleavage of the α-glycosidic bond by α-L-iduronidase (IDUA) to release 4-methylumbelliferone

β-D-(Galβ1-4Glc)-O-(CH2)2-NH2

This compound presents the Blood Group B trisaccharide (Galα1-3[Fucα1-2]Gal)

α2-6 sialosides are ligands for Siglecs and human-type influenza hemagglutinin